Pancreatic cancer microenvironment
نویسندگان
چکیده
منابع مشابه
The pancreatic cancer microenvironment: an immunologic battleground
Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8+ T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the clinical evaluation of immune checkpoint inhibition as a pancreatic cancer therapeutic strategy.
متن کاملPancreatic CSCs and microenvironment
Pancreatic ductal adenocarcinoma (PDAC) is the most common malignant neoplasm of the pancreas and presents with dismal prognosis. Key hallmarks of these tumors are chemo resistance and early metastasis, leaving few effective options for curative treatment. In part, treatment resistance might be spawned by tumor cell plasticity within pancreatic cancers, and specifically by therapy resistant pan...
متن کاملREG3β contributes to the immunosuppressive microenvironment of pancreatic cancer
The levels of regenerating islet-derived 3β (REG3β) in the serum and pancreatic juice of patients affected by pancreatic ductal adenocarcinomas are increased. However, whether such an elevation is relevant to oncogenesis and tumor progression has not yet been carefully examined. We have recently demonstrated that silencing REG3β in a pancreatic cancer model impairs tumor growth by skewing macro...
متن کاملSeed-in-Soil: Pancreatic Cancer Influenced by Tumor Microenvironment
Pancreatic ductal adenocarcinoma is a fatal malignancy with a five-year survival rate lower than 7%, and most patients dying within six months of diagnosis. The factors that contribute to the aggressiveness of the disease include, but are not limited to: late diagnosis, prompt metastasis to adjacent vital organs, poor response, and resistance to anticancer treatments. This malignancy is uniquel...
متن کاملPancreatic cancer microenvironment, to target or not to target?
We have collectively been spoiled by the astounding clinical benefit of antimicrobials. Much like the discovery and use of penicillin to eradicate once deadly infections, we continue to desperately search for the next “magic bullet” to kill cancer while sparing the non‐transformed cells. Greater appreciation for the molecular intricacies of malignancy has resulted in dedicated pursuit of cancer...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2007
ISSN: 0020-7136,1097-0215
DOI: 10.1002/ijc.22871